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1 Ιουλ 2023 · The TiO 2 NPs have been used in drug delivery and combined cancer treatments due to their ability to reach drug release in cancer cells, their autophagic, photodynamic characteristics, and their non-toxicity up to a concentration of 1 μg mL −1 for normal cells.
26 Ιαν 2021 · Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutation Research, Fundamental and Molecular Mechanisms of Mutagenesis.
It has been reported that the elevated level of oxidative stress by exogenous agents, due to the elevation of ROS in tumor environment, can be more destructive in cancer cells. 41 Prior studies have shown that induction of ROS production in a tumor environment triggers apoptosis, which is the appropriate type of cell death in cancers. 42 Thus ...
4 Νοε 2021 · In this work, we systematically studied the interactions between three sizes of TiO 2 particles and the cell membrane systems with confocal laser scanning microscopy. We used both giant unilamellar vesicles and human colon cancer cells to mimic actual cell membrane systems.
2 Σεπ 2022 · We performed a 26-week inhalation exposure studies of titanium dioxide nanoparticles (TiO2 NPs) using CByB6F1-Tg(HRAS)2Jic (rasH2) mice model for detecting carcinogenicity.
15 Οκτ 2022 · TiO 2 NPs are considered toxic due to their production of reactive oxygen species (ROS), which can, among others, lead to cellular damage, inflammatory responses, and differences in gene expression.
Importantly, the use of a SOD corona or surface passivated TiO2 nanoparticles prevents the decrease of HDAC9. These expts. elucidate the underlying mechanism of TiO2 nanoparticle-mediated cellular responses including oxidative stress and changes in gene expression.
