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22 Μαΐ 2023 · The TRANSFORM-HF trial (Torsemide Comparison With Furosemide for Management of Heart Failure) was an open-label, pragmatic, randomized study designed to compare the effect of torsemide versus furosemide after discharge among patients hospitalized for HF.
- Abstract 14756: The Effect of Torsemide vs Furosemide Across the Renal ...
The interaction between baseline renal function and...
- Abstract 14756: The Effect of Torsemide vs Furosemide Across the Renal ...
24 Ιαν 2023 · The loop diuretics are highly protein bound and therefore enter the tubule primarily by secretion in the proximal tubule, rather than by glomerular filtration [1]. The most commonly used loop diuretics are furosemide, bumetanide, and torsemide, which are sulfonamide derivatives.
Torsemide is a loop diuretic prescribed for a minority of patients with heart failure and renal disease, despite growing evidence for its potential advantages. Torsemide demonstrates superior pharmacodynamics and pharmacokinetics compared with furosemide.
3 Ιουλ 2023 · Torsemide does not affect renal blood flow or glomerular filtration rate (GFR). However, studies have also shown that genetics can play a role in the drug response of various loop diuretics, including torsemide.
6 Νοε 2023 · The interaction between baseline renal function and treatment effect of torsemide vs furosemide was assessed for endpoints of (1) all-cause mortality and (2) all-cause mortality and all-cause readmissions at 12 months.
Growing evidence demonstrates more favorable pharmacokinetic profiles of torsemide and bumetanide compared with furosemide. Furthermore, torsemide may be more efficacious and safer than furosemide in patients with HF.
1 Ιαν 2020 · Although torsemide's oral bioavailability and half-life theoretically render it a more efficient diuretic than furosemide, the clinical outcomes of torsemide compared with furosemide remain unclear. We performed a systematic review and meta-analysis, including all published studies that compared torsemide and furosemide use in heart failure ...
