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TFA is often used in HTP laboratories to control peak shape of basic compounds by ensuring residual silanols ubiquitous in the silica-based C18 columns are in their neutral charge state.
- Trifluoroacetic Acid
Trifluoroacetic acid is used industrially in peptides...
- Trifluoroacetic Acid
Trifluoroacetic acid is used industrially in peptides production. In the laboratory, C 2 HF 3 O 2 is also widely used in low concentrations in eluents for liquid chromatography [69] . It is one of the strongest carboxylic acids ( i.e. p K a = 0.3) and easily soluble in both water and organic solvents, which favors the skin penetration and ...
Trifluoroacetic acid (TFA) is a synthetic organofluorine compound with the chemical formula CF 3 CO 2 H. It is a haloacetic acid, with all three of the acetyl group's hydrogen atoms replaced by fluorine atoms. It is a colorless liquid with a vinegar -like odor.
1 Δεκ 2013 · Trifluoroacetic acid has been used as the reagent of choice for the removal of nitrogen and oxygen protecting groups by solvolysis under aqueous or anhydrous conditions. Different methods for the cleavage of O - and N - protecting groups by TFA are given below.
1 Δεκ 2013 · Trifluoroacetic acid (TFA), discovered at the early 20th century, has been widely used in organic synthesis as a solvent, catalyst and reagent. Many chemical transformations should be done...
5 Αυγ 2020 · With innovative purification technologies, the fluorochemical experts at Halocarbon continue to support large-scale production of high-purity BioGrade® TFA for use in both laboratory-scale procedures and analysis to manufacturing-scale peptide synthesis and peptide purification.
8 Ιουν 2023 · Since its discovery at the beginning of the 20 th century, trifluoroacetic acid, commonly known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/ reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements, functional group deprotections ...
