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10 Αυγ 2020 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...
Uracil (/ ˈ j ʊər ə s ɪ l /) (symbol U or Ura) is one of the four nucleotide bases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine (T). Uracil is a demethylated form of thymine.
1 Δεκ 2010 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication.
16 Ιαν 2023 · A uracil DNA glycosylase, UDG/SMUG1/TDG/MBD4 in humans, detects and ‘flips’ out the uracil base from the DNA and cleaves it, leaving an abasic site. AP endonuclease (APE) then nicks the DNA backbone 5′ to the abasic site, creating a single-strand DNA break.
1 Δεκ 2010 · The presence of uracil in DNA is deleterious for living organisms including yeast, bacteria, and humans; it can result either from spontaneous or enzymatic deaminations of cytosines or...
Uracil, typically found in RNA, can occasionally be incorporated into DNA, leading to potential genomic instability. This incorporation challenges the fidelity of genetic information and may have implications for cellular function and disease progression.
