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16 Ιαν 2023 · A uracil DNA glycosylase, UDG/SMUG1/TDG/MBD4 in humans, detects and ‘flips’ out the uracil base from the DNA and cleaves it, leaving an abasic site. AP endonuclease (APE) then nicks the DNA backbone 5′ to the abasic site, creating a single-strand DNA break.
Uracil (U) is an essential component of the genetic code in all organisms and is one of the four nucleobases that make up the nucleic acid of RNA. It plays a significant role in metabolism, protein synthesis, and DNA replication (Eckert et al., 2018).
16 Δεκ 2002 · Abstract. Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different...
1 Δεκ 2010 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication.
10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….
6 ημέρες πριν · Uracil (U) is one of the four nucleotide bases in RNA, with the other three being adenine (A), cytosine (C) and guanine (G). In RNA, uracil pairs with adenine. In a DNA molecule, the nucleotide thymine (T) is used in place of uracil.
28 Σεπ 2010 · Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil–DNA–glycosylases (UDG). Recent studies suggest that recognition of U–A and U–G mismatches by UDG takes place via an extra-helical mechanism.
