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16 Δεκ 2002 · UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also indicates an important role in repair of U : G mispairs...
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1 Δεκ 2010 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication.
1 Ιαν 2003 · UNG2 is a major nuclear uracil-DNA glycosylase central in removal of misincorporated dUMP in replication foci, but recent evidence also indicates an important role in repair of U : G mispairs and...
The lower panel lists the specific DNA repair pathways that are instigated to repair DNA damages: mismatch repair corrects replication errors and other base mismatches; base excision repair removes base adducts, uracil, abasic sites and oxidative lesions; single strand break repair pathways repairs single stranded breaks in the DNA backbone ...
1 Ιουν 2007 · The discovery of uracil-DNA glycosylase in Escherichia coli and subsequently other DNA glycosylases revealed that repair of small base lesions by the process called base excision repair (BER) is a universal DNA repair pathway found in prokaryotes and eukaryotes.
9 Νοε 2001 · Uracil-initiated base excision DNA repair was conducted using homozygous mouse embryonic fibroblast DNA polymerase β (+/+) and (−/−) cells to determine the error frequency and mutational specificity associated with the completed repair process.
1 Νοε 2008 · Uracil in DNA comes in two distinct forms; U:A pairs, typically resulting from replication errors, and mutagenic U:G mismatches, arising from cytosine deamination. To identify proteins critical to the rate of repair of these lesions, we quantified overall repair of U:A pairs, U:G mismatches and repair intermediates (abasic sites and nicked ...
