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16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human...
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1 Δεκ 2010 · Mammalian cells contain four main UDGs: uracil-DNA glycosylase (UNG) encoded by the Ung gene (in two forms: mitochondrial-UNG1 and nuclear-UNG2), single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1), T/U mismatch DNA glycosylase (TDG) and methyl-binding domain 4 protein (MBD4).
9 Απρ 2021 · Here, we provide a summary of diverse uracil-DNA detection methods with their advantages and limitations, and discuss their results and conclusions. We detail the global quantitative U-detection methods as well as various emerging solutions for in situ uracil-DNA detection.
9 Σεπ 2008 · In humans, a significant inverse correlation was reported between uracil misincorporation in lymphocyte DNA and red blood cell folate . Folate supplementation resulted in a decrease in uracil incorporation in DNA, and genomic uracil was reported to serve as a marker of folate status.
21 Σεπ 2020 · Using UGI expressing cell lines, we aimed to reveal the nascent pattern of uracil moieties in DNA induced by perturbation of thymidylate metabolism both using genome-wide uracil-specific sequencing and in situ cellular imaging of uracils within human genomic DNA.
Uracil in DNA is removed by a uracil-DNA glycosylase. The major ones are nuclear UNG2 and mitochondrial UNG1 encoded by the UNG-gene, and SMUG1 that also removes oxidized pyrimidines, e.g. 5-hydroxymethyluracil.
Genomic uracil is a DNA lesion but also an essential key intermediate in adaptive immunity. In B cells, activation-induced cytidine deaminase deaminates cytosine to uracil (U:G mispairs) in Ig genes to initiate antibody maturation.
