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1. academic.oup.com › nar › articleone-step method for quantitative determination of uracil in DNA...

   academic.oup.com › nar › article

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   22 Σεπ 2010 · Uracil may occur in DNA due to either cytosine deamination or thymine replacing incorporation. Its quantitative characterization is important in assessing DNA damages in cells with perturbed thymidylate metabolism or within different DNA segments involved in immunoglobulin gene diversification.

2. academic.oup.com › nar › articleDetection of uracil within DNA using a sensitive labeling method...

   academic.oup.com › nar › article

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   1 Οκτ 2015 · The role of uracil in genomic DNA has been recently re-evaluated. It is now widely accepted to be a physiologically important DNA element in diverse systems from specific phages to antibody maturation and Drosophila development.

3. www.nature.com › articles › 1205996Uracil in DNA – occurrence, consequences and repair | Oncogene -...

   www.nature.com › articles › 1205996

   16 Δεκ 2002 · At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These enzymes are UNG, SMUG1, TDG and...

4. link.springer.com › article › 10A rapid, safe, and quantitative in vitro assay for ... - Springer

   link.springer.com › article › 10

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   1 Μαΐ 2019 · Uracil is one of the most prevalent lesions that appears in DNA arising by spontaneous or enzymatic deamination of cytosine or misincorporation of the deoxyuridine 5′-triphosphate nucleotide (dUTP) in place of deoxythymidine 5′-triphosphate (dTTP) during DNA replication.

5. ncbi.nlm.nih.gov › pmc › articlesAn assay for uracil in human DNA at baseline: effect of marginal...

   ncbi.nlm.nih.gov › pmc › articles

   1 Ιαν 2008 · In order to detect more accurately low baseline lymphocyte DNA-uracil content of healthy human DNA, further modifications were made to the uracil assay; this most recent version of the assay will hereafter be referred to as “Uracil assay V3.”

6. www.ncbi.nlm.nih.gov › pmc › articlesDetection of Genomic Uracil Patterns - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   9 Απρ 2021 · Here, we provide a summary of diverse uracil-DNA detection methods with their advantages and limitations, and discuss their results and conclusions. We detail the global quantitative U-detection methods as well as various emerging solutions for in situ uracil-DNA detection.

7. pubmed.ncbi.nlm.nih.gov › 20709185Uracil in DNA--its biological significance - PubMed

   pubmed.ncbi.nlm.nih.gov › 20709185

   10 Αυγ 2020 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...