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31 Μαΐ 2022 · Here, we show that Ki-67 plays a key role to mediate the relocation of pre-rRNAs to mitotic chromosomes. Similar to Ki-67, pre-rRNAs are evenly distributed to the chromosome periphery. Ki-67...
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6 Μαρ 2023 · Model of RNA transcript localization to the mitotic spindle. RNA transcripts that encode proteins that regulate mitosis are localized to the mitotic spindle. Microtubule motors kinesin-1 and dynein are involved in the transport of these RNA transcripts.
The first step involves RNA polymerase, an enzyme that unwinds and unzips the double helix to access a protein-coding gene. The gene's DNA sequence is used as the template for transcribing an RNA copy of that gene, which the polymerase assembles from a chain of nucleotides.
20 Σεπ 2022 · RNA modifications have been used to allow mRNA vaccines to evade the innate immune response. RNA is also ‘edited’ by cytosine and adenosine deamination, to form uracil and inosine, respectively.
1 Ιαν 2020 · Vast classes of molecules including noncoding RNAs also play critical roles in numerous biological processes. Cell division via mitosis and meiosis allows for the division of parent cells and dissemination of genetic information.
20 Ιουν 2019 · Highlights. During mitosis, chromosomes reorganise into compact cylindrical bodies so that the spindle can distribute one copy of the genome to each daughter cell. Condensins are key organisers of mitotic chromosome topology, with accumulating evidence that they achieve this through the extrusion of DNA into loops.
Cells Produce Several Types of RNA. The majority of genes carried in a cell's DNA specify the amino acid sequence of proteins; the RNA molecules that are copied from these genes (which ultimately direct the synthesis of proteins) are called messenger RNA (mRNA) molecules.
