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9 Ιουν 2017 · The present brief review discusses the physicochemical parameters underlying the specific ultraviolet-induced reactivity of methylated cytosine. It focuses on dimerization reactions giving rise...
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UVB light is the form of UV light that is responsible for tanning and burning. Sunscreens work to protect from both UVA and UVB rays. Overall, sunburns exemplify DNA damage caused by UV rays, and this damage can come in the form of free radical species, as well as dimerization of adjacent nucleotides.
In this chapter, the detailed methodology to identify thymine dimers formation is provided, using specific antibody against these adducts. Keywords: Chemiluminescence; DNA damage; Southern blotting; Thymine dimer; UV radiation.
Cyclobuthane thymine dimer is a photolesion produced by UV radiation in sunlight and is considered as a potential factor causing skin cancer. It is formed as a covalently bonded complex of two adjacent thymines on a single strand of DNA.
UVB radiation-induced formation of dimeric photoproducts at bipyrimidine sites within DNA has been unambiguously associated with the lethal and mutagenic properties of sunlight. The main lesions include the cyclobutane pyrimidine dimers and the pyrimidine (6-4) pyrimidone adducts.
1 Σεπ 2019 · Ultraviolet (UV) radiation exposure can induce cellular DNA damage in living organisms. It may cause genetic mutations, cell death or cellular transformation [melanoma, basal cell carcinoma and squamous cell carcinoma] [1]. UV exposure usually forms thymine–thymine cyclobutane dimer (TT) and thymine–thymine pyrimidine–pyrimidone (6-4 ...
20 Σεπ 2002 · UV light induced thymine dimer formation (cis–syn stereoisomer) between two adjacent thymine bases in the same strand of a DNA molecule. The photoreactivation process is catalyzed by DNA photolyase, which uses near-UV and visible light.
