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UmuD′ 2 C is known to bypass thymine– thymine dimers caused by UV radiation, as well as abasic sites that arise via multiple mechanisms. UmuD′ 2 C is regulated as part of the SOS response and performs potentially mutagenic translesion synthesis (TLS) to replicate damaged DNA.
- Radical Cation
Radical cations can exhibit the tendency to dimerize, either...
- Radical Cation
Pyrimidine dimers represent molecular lesions originating from thymine or cytosine bases within DNA, resulting from photochemical reactions. [1][2] These lesions, commonly linked to direct DNA damage, [3] are induced by ultraviolet light (UV), particularly UVC, result in the formation of covalent bonds between adjacent nitrogenous bases along th...
1 Σεπ 2019 · Ultraviolet (UV) radiation exposure can induce cellular DNA damage in living organisms. It may cause genetic mutations, cell death or cellular transformation [melanoma, basal cell carcinoma and squamous cell carcinoma] [1]. UV exposure usually forms thymine–thymine cyclobutane dimer (TT) and thymine–thymine pyrimidine–pyrimidone (6-4 ...
Direct repair of thymine dimers. UV-induced thymine dimers can be repaired by photoreactivation, in which energy from visible light is used to split the bonds forming the cyclobutane ring. Another form of direct repair deals with damage resulting from the reaction between alkylating agents and DNA.
28 Σεπ 2016 · In this paper we investigate whether UV exposure triggers T <> T dimer formation in the singlet or triplet manifold. To this aim, we report the first ab initio nonadiabatic molecular dynamics simulations of a stacked thymine dimer including all relevant singlet and triplet states.
2 Φεβ 2007 · The most abundant lesion in ultraviolet (UV)–irradiated DNA is the cyclobutane pyrimidine dimer (CPD) that is formed between adjacent thymine bases . This mutagenic photoproduct disrupts the normal cellular processing of DNA and leads to a complex web of biological responses, including apoptosis, immune suppression, and carcinogenesis ( 2 ...
20 Σεπ 2002 · UV light induced thymine dimer formation (cis–syn stereoisomer) between two adjacent thymine bases in the same strand of a DNA molecule. The photoreactivation process is catalyzed by DNA photolyase, which uses near-UV and visible light.
