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1 Σεπ 2019 · Ultraviolet (UV) radiation exposure can induce cellular DNA damage in living organisms. It may cause genetic mutations, cell death or cellular transformation [melanoma, basal cell carcinoma and squamous cell carcinoma] [1]. UV exposure usually forms thymine–thymine cyclobutane dimer (TT) and thymine–thymine pyrimidine–pyrimidone (6-4 ...
9 Ιουν 2017 · Signal Transduction and Targeted Therapy - When UV radiation is absorbed by DNA bases, these letters of the genetic code may be chemically tagged giving rise to carcinogenic mutations. In a...
2 Φεβ 2007 · The most abundant lesion in ultraviolet (UV)–irradiated DNA is the cyclobutane pyrimidine dimer (CPD) that is formed between adjacent thymine bases . This mutagenic photoproduct disrupts the normal cellular processing of DNA and leads to a complex web of biological responses, including apoptosis, immune suppression, and carcinogenesis ( 2 ...
Cyclobuthane thymine dimer is a photolesion produced by UV radiation in sunlight and is considered as a potential factor causing skin cancer. It is formed as a covalently bonded complex of two adjacent thymines on a single strand of DNA.
Thymine dimerization is the main photochemically induced lesion occurring in UV-irradiated DNA and an understanding of the mechanisms of direct and photosensitized dimerization is of biological importance.
Thymine dimers are induced in human skin by UV radiation in sunlight and are a primary cause of skin cancer [2]. Thymine dimers form when two adjacent thymine residues are covalently bonded on a single strand of DNA, causing a ‘kink’.
1 Μαρ 2008 · Major lesions found in DNA after in vitro or in vivo UV irradiation are the cis-syn cyclobutane thymine dimer and the thymine-cytosine (6-4) photoproduct.
