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25 Ιουν 2023 · Here, we performed a detailed analysis of drug-sensitive ovarian cancer cell lines (A2780 and W1) and the influence of ovarian CAFs on the A2780 and W1 cells morphology, genes and proteins expression.
The serous ovarian cancer cell line A2780 and its platinum-resistant counterpart A2780-cp were used in this study. We performed a lectin array analysis to compare the glycosylation patterns of the two cell lines, a gene expression array was employed to probe the differences in glycogenes. Furthermore, the results were verified by lectin blots ...
We also tested in A2780 ovarian cancer cells the combined antitumor effect of gemcitabine and topotecan, demonstrating an antagonistic effect in terms of growth inhibition, clonogenic ability and DNA analysis [27].
25 Ιουν 2023 · Methods: Here, we performed a detailed analysis of drug-sensitive ovarian cancer cell lines (A2780 and W1) and the influence of ovarian CAFs on the A2780 and W1 cells morphology, genes and proteins expression.
We have characterized 39 ovarian cancer cell lines under uniform conditions for growth characteristics, mRNA/microRNA expression, exon sequencing, drug response for clinically-relevant therapeutics and collated all available information on the original clinical features and site of origin.
18 Αυγ 2017 · Interestingly, chemosensitive cancer cell lines (A2780 and PEO1) displayed a glycolytic phenotype while their chemoresistant counterparts (C200 and PEO4) exhibited a high metabolically active...
21 Μαρ 2019 · In order to identify differentially expressed genes (DEGs) that are relevant to the chemoresistant phenotype in ovarian cancer cell lines, we performed an expression analysis on parental A2780 and CBDCA-R-A2780 cell lines using RNA-seq. A total of 14.673 protein-coding genes were sequenced.
