Αποτελέσματα Αναζήτησης
2 Σεπ 2020 · The difference in lipid composition between the cellular membranes of healthy cells and tumor cells allows for the development of novel therapies based on targeting membrane lipids in cancer cells to increase sensitivity to chemotherapeutic agents and consequently defeat multidrug resistance.
26 Ιουλ 2020 · Molecular dynamics studies showed that the loss of lipid asymmetry, observed in cancer cells, leads to a decrease in their permeability (Rivel et al. 2019). In this review paper, we present a comprehensive overview of alterations in the lipid profile of the cell membrane of cancer in correlation with its biological significance.
25 Ιαν 2024 · Cancer cells containing membrane lipids that are rich in saturated fatty acids or MUFAs show a strong dependence on SCD to prevent ER stress and cell death.
16 Μαΐ 2019 · Fatty acid synthase (FASN), the rate-limiting enzyme in the FA synthesis pathway, has been widely reported to promote cancer progression. 3 However, studies have shown that cancer cells can...
9 Αυγ 2022 · Abstract. Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer...
17 Μαΐ 2024 · In this review we provide an integrated overview of emerging lipid metabolic targets related to FAS, fatty acid uptake, and lipid desaturation in cancer cells. In addition, we describe emerging strategies that exploit lipid metabolism to overcome cell death resistance in cancer cells.
Cancer cells display altered cellular lipid metabolism, including disruption in endogenous lipid synthesis, storage, and exogenous uptake for membrane biogenesis and functions.
