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1. www.ncbi.nlm.nih.gov › books › NBK559112Valproic Acid - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK559112

   19 Μαρ 2024 · Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis.

2. pmc.ncbi.nlm.nih.gov › articles › PMC3696515Valproic acid pathway: pharmacokinetics and pharmacodynamics

   pmc.ncbi.nlm.nih.gov › articles › PMC3696515

   Valproic acid (VPA) is a branched short-chain fatty acid derived from naturally occurring valeric acid. VPA is used primarily in the treatment of epilepsy and seizures, but is also used in migraine, bipolar, mood, anxiety, and psychiatric disorders [1].

3. pmc.ncbi.nlm.nih.gov › articles › PMC7052829Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical...

   pmc.ncbi.nlm.nih.gov › articles › PMC7052829

   The aim of this review is to analyze both clinical and preclinical aspects regarding the use of valproic acid (N-dipropylacetic acid or VPA), moving from preclinical evidences of anticonvulsant activity and neuroprotection to clinical data on efficacy and tolerability profile both in the pediatric and adult population.

4. pubmed.ncbi.nlm.nih.gov › 32644538Valproic Acid - PubMed

   pubmed.ncbi.nlm.nih.gov › 32644538

   19 Μαρ 2024 · Valproic acid (VPA) ia as a highly prevalent medication with multifaceted therapeutic applications in various neurological and psychiatric disorders. The therapeutic uses of VPA include epilepsy treatment across different seizure types, bipolar disorder management, and migraine prophylaxis.

5. pubmed.ncbi.nlm.nih.gov › 12269862Pharmacological and therapeutic properties of valproate: a...

   pubmed.ncbi.nlm.nih.gov › 12269862

   Valproic Acid. Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects involve a variety of mechanisms, including increased gamma-aminobutyric acid (GABA)-ergic transmission, reduced ….

6. pmc.ncbi.nlm.nih.gov › articles › PMC5903263A systematic review of population pharmacokinetics of valproic...

   pmc.ncbi.nlm.nih.gov › articles › PMC5903263

   Population pharmacokinetics is an essential tool that helps guide individualized dosing regimens. The aims of this systematic review are to provide knowledge concerning population pharmacokinetics of valproic acid (VPA) and to identify factors influencing VPA pharmacokinetic variability.

7. pubmed.ncbi.nlm.nih.gov › 30592252Valproic Acid and Epilepsy: From Molecular Mechanisms to ... -...

   pubmed.ncbi.nlm.nih.gov › 30592252

   Abstract. After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regulation of ionic currents and the facilitation of GABAergic over glutamatergic transmission.