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Doxycycline may increase the blood-thinning effects of warfarin in some patients. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring of your INR to safely use both medications.
This is a partial list of medications that may increase or decrease warfarin effect on the INR. The patient's medications should be analyzed closely for drug interactions with warfarin, especially when initiating or altering therapy.
We identified that the likelihood of an INR of 5.0 or more varies substantially depending on the antibiotic prescribed and the warfarin interaction mechanism.
Doxycycline can enhance the anticoagulant effect of warfarin. This is likely due to competitive interaction for albumin binding and possibly inhibition of the cytochrome P-450 system. An increase in plasma levels of free warfarin may result in severe bleeding.
27 Μαΐ 2022 · Both warfarin and direct oral anticoagulants are susceptible to drug-drug interactions (DDIs). DDIs are an important cause of adverse drug reactions and exact a large toll on the health care system.
26 Μαρ 2021 · This review found low to moderate certainty evidence supporting the interaction between warfarin and a small group of medications, which result in increased bleeding risk. PPIs are associated with reduced hospitalization for upper GI bleeding for patients taking warfarin.
13 Νοε 2023 · Review detailed drug interaction details between Doxycycline and Warfarin, including severity, interaction details, how to manage the interaction, and more.
