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1. www.nature.com › articles › 1205996Uracil in DNA – occurrence, consequences and repair | Oncogene -...

   www.nature.com › articles › 1205996

   16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine to uracil, creating a premutagenic U : G mispair, or from misincorporation of dUMP instead of dTMP during replication, creating a U : A...

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2. pubmed.ncbi.nlm.nih.gov › 20709185Uracil in DNA--its biological significance - PubMed

   pubmed.ncbi.nlm.nih.gov › 20709185

   10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….

3. www.ncbi.nlm.nih.gov › pmc › articlesUracil in DNA: consequences for carcinogenesis and chemotherapy

   www.ncbi.nlm.nih.gov › pmc › articles

   9 Σεπ 2008 · Among the potential sources of DNA damage, uracil misincorporation into DNA and its removal by base excision repair (BER) has been the most commonly presumed source.

4. www.sciencedirect.com › science › articleUracil in DNA—Its biological significance - ScienceDirect

   www.sciencedirect.com › science › article

   1 Δεκ 2010 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...

5. www.ncbi.nlm.nih.gov › books › NBK9900DNA Repair - The Cell - NCBI Bookshelf - National Center for ...

   www.ncbi.nlm.nih.gov › books › NBK9900

   The excision of uracil in DNA is catalyzed by DNA glycosylase, an enzyme that cleaves the bond linking the base (uracil) to the deoxyribose of the DNA backbone. This reaction yields free uracil and an apyrimidinic site—a sugar with no base attached.

6. pmc.ncbi.nlm.nih.gov › articles › PMC5474181Mechanisms of DNA damage, repair and mutagenesis - PMC

   pmc.ncbi.nlm.nih.gov › articles › PMC5474181

   In terms of function, DNA glycosylases are either monofunctional, with only a glycosylase activity, such as the uracil glycosylases, N-methylpurine DNA Glycosylase (MPG), and MutY Homolog (MUTYH), or are bifunctional with a glycosylase and an additional β-lyase activity.

7. www.ncbi.nlm.nih.gov › pmc › articlesDetection of Genomic Uracil Patterns - PMC - National Center for...

   www.ncbi.nlm.nih.gov › pmc › articles

   9 Απρ 2021 · Here, we provide a summary of diverse uracil-DNA detection methods with their advantages and limitations, and discuss their results and conclusions. We detail the global quantitative U-detection methods as well as various emerging solutions for in situ uracil-DNA detection.