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1. www.nature.com › articles › 1205996Uracil in DNA – occurrence, consequences and repair | Oncogene -...

   www.nature.com › articles › 1205996

   16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human...

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2. pubmed.ncbi.nlm.nih.gov › 20709185Uracil in DNA--its biological significance - PubMed

   pubmed.ncbi.nlm.nih.gov › 20709185

   10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….

3. www.ncbi.nlm.nih.gov › pmc › articlesUracil in DNA: consequences for carcinogenesis and chemotherapy

   www.ncbi.nlm.nih.gov › pmc › articles

   9 Σεπ 2008 · Genomic uracil is removed by uracil DNA glycosylases of base excision repair (BER). Unfortunately, BER is apparently problematic during thymidylate stress. Because BER requires a DNA resynthesis step, elevated dUTP causes reintroduction of genomic uracil.

4. www.sciencedirect.com › science › articleUracil in DNA—Its biological significance - ScienceDirect

   www.sciencedirect.com › science › article

   1 Δεκ 2010 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...

5. pmc.ncbi.nlm.nih.gov › articles › PMC5474181Mechanisms of DNA damage, repair and mutagenesis - PMC

   pmc.ncbi.nlm.nih.gov › articles › PMC5474181

   The lower panel lists the specific DNA repair pathways that are instigated to repair DNA damages: mismatch repair corrects replication errors and other base mismatches; base excision repair removes base adducts, uracil, abasic sites and oxidative lesions; single strand break repair pathways repairs single stranded breaks in the DNA backbone ...

6. pubs.acs.org › doi › absKeeping Uracil Out of DNA: Physiological Role, Structure and...

   pubs.acs.org › doi › abs

   7 Οκτ 2008 · There are two ways for uracil to appear in DNA: thymine replacement and cytosine deamination. Most DNA polymerases readily incorporate dUMP as well as dTMP depending solely on the availability of the d(U/T)TP building block nucleotides.

7. pubmed.ncbi.nlm.nih.gov › 12483510Uracil in DNA--occurrence, consequences and repair - PubMed

   pubmed.ncbi.nlm.nih.gov › 12483510

   16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic.