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16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human...
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9 Σεπ 2008 · Increased uracil in DNA is observed under conditions of TLS (Figure 2). In humans, a significant inverse correlation was reported between uracil misincorporation in lymphocyte DNA and red blood cell folate [ 6 ].
1 Ιαν 2003 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human...
10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic.
28 Σεπ 2010 · Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil–DNA–glycosylases (UDG). Recent studies suggest that recognition of U–A and U–G mismatches by UDG takes place via an extra-helical mechanism.
1 Δεκ 2010 · Uracil existing in DNA may arise as a result of spontaneous deamination of cytosine (leading to U:G mispairing) or from incorporation of dUMP during replication in place of dTMP leading to U:A pairing.
