Αποτελέσματα Αναζήτησης
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA...
- Metrics
We would like to show you a description here but the site...
- Full Size Table
We would like to show you a description here but the site...
- Metrics
22 Σεπ 2010 · Uracil may occur in DNA due to either cytosine deamination or thymine replacing incorporation. Its quantitative characterization is important in assessing DNA damages in cells with perturbed thymidylate metabolism or within different DNA segments involved in immunoglobulin gene diversification.
9 Σεπ 2008 · In the first step of BER, UDG activity catalyzes uracil release and produces an abasic site in DNA. AP endonuclease produces a nick 5′ to the abasic site. The dRP lyase activity of pol β creates a 5′-phosphate and polymerase activity fills the one nucleotide gap in short-patch BER.
The presence of uracil in DNA arises through several mechanisms. One primary route is the spontaneous deamination of cytosine, converting it into uracil. This chemical transformation can occur under physiological conditions, leading to the mispairing of bases during DNA replication.
10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication. In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the I ….
28 Σεπ 2010 · Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil–DNA–glycosylases (UDG). Recent studies suggest that recognition of U–A and U–G mismatches by UDG takes place via an extra-helical mechanism.
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic.
