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16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA...
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9 Σεπ 2008 · Because of the close relationship between dUMP and TMP, thymidylate stress is associated with increased incorporation of uracil into DNA. Genomic uracil is removed by uracil DNA glycosylases of base excision repair (BER). Unfortunately, BER is apparently problematic during thymidylate stress.
The presence of uracil in DNA arises through several mechanisms. One primary route is the spontaneous deamination of cytosine, converting it into uracil. This chemical transformation can occur under physiological conditions, leading to the mispairing of bases during DNA replication.
1 Ιαν 2003 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human...
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic.
10 Αυγ 2020 · Uracil may arise in DNA as a result of spontaneous cytosine deamination and/or misincorporation of dUMP during DNA replication.
The removal of uracil from genomic DNA takes place primarily by the base excision repair (BER) 2 pathway initiated by specific uracil-DNA glycosylases (UDGs), four of which are expressed in human cells (UNG1/UNG2, SMUG1, TDG, and MBD4) (4).
