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29 Δεκ 2020 · Immunosuppressive effects of cannabinoids raise concerns about their attempted uses in cancer treatment. THC has been shown to inhibit the host’s immune response to cancer cells in a murine lung cancer model, consequently stimulating tumor growth, and similar findings have been reported in a murine breast cancer study .
- Cannabinoids in cancer treatment: Therapeutic potential and legislation ...
The ability of plant-derived and synthetic cannabinoids to...
- Cannabinoids in the landscape of cancer - PubMed
Introduction: Cannabinoids are a group of terpenophenolic...
- Cannabinoids in cancer treatment: Therapeutic potential and legislation ...
Cannabinoids can induce autophagy in several cell lines and mouse models of cancer. The most important mechanism by which cannabinoids cause autophagy is the accumulation of ceramide in tumor cells. Cannabinoids increase ceramide concentration in the cell by two mechanisms.
Cannabinoids, including Δ9-THC, CBD, and CBG, exhibit significant anticancer activities such as apoptosis induction, autophagy stimulation, cell cycle arrest, anti-proliferation, anti-angiogenesis, and metastasis inhibition. Clinical trials have demonstrated cannabinoids’ efficacy in tumor regression and health improvement in palliative care.
The ability of plant-derived and synthetic cannabinoids to control cancer cell growth, invasion, and death has been demonstrated in numerous experimental studies using cancer cell lines and genetically engineered mouse models.
18 Μαΐ 2021 · We discovered that Δ 9-THC mediated cross-talk between cancer cells and vascular endothelial cells via a STAT1-dependent manner in CRC. A long-term follow-up of cannabinoids in patients with...
11 Μαρ 2022 · Research in recent years has yielded several compounds that exert promising effects on tumour cells and tissues in addition to the psychoactive Δ 9 -tetrahydrocannabinol, such as the...
Introduction: Cannabinoids are a group of terpenophenolic compounds derived from the Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal studies in support of cannabinoids possessing anticancer properties.
