Αποτελέσματα Αναζήτησης
The effects of THC are mediated through the endocannabinoid system (ECS), which promotes a positive energy balance through stimulation of appetite as well as shifting homeostatic mechanisms toward energy storage. Here we discuss the physiological function of the ECS in energy balance and the therapeutic potential of targeting this system.
In general, pathological overactivation of the ECS contributes to weight gain, reduced sensitivity to insulin and glucose intolerance, and blockade of CB1 receptors reduces body weight through increased secretion of anorectic signals and improved insulin sensitivity.
11 Ιουλ 2022 · More specifically, we focus on recent advances underlying mechanisms of endocannabinoid control of cell metabolism through the modulation of the functions of specific organelles.
26 Απρ 2005 · Abstract. Marijuana and its major psychotropic component, Δ 9 -tetrahydrocannabinol, stimulate appetite and increase body weight in wasting syndromes, suggesting that the CB 1 cannabinoid...
Endocannabinoids and cannabinoid CB1 receptors are known to play a generalized role in energy homeostasis. However, clinical trials with the first generation of CB1 blockers, now discontinued due to psychiatric side effects, were originally designed to reduce food intake and body weight rather than the metabolic risk factors associated with ...
16 Σεπ 2015 · An overactive endocannabinoid cannabinoid type 1 (CB 1) receptor signaling promotes the development of obesity, insulin resistance and dyslipidemia, representing a valuable pharmacotherapeutic...
28 Απρ 2021 · In this review the authors focus on the endogenous cannabinoids, and the critical role of cannabinoid receptor signaling in neurodegeneration and other inflammatory responses such as gut, joint and skin inflammation.
