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We propose that under normal physiological conditions cannabinoid signalling in the endocrine pancreas is a bona fide mechanism of regulating insulin secretion to maintain blood glucose levels, but that energy balance becomes dysregulated with excessive food intake, leading to adipogenesis and fat accumulation through enhanced cannabinoid ...
Numerous studies have documented the analgesic effects of cannabinoids in different types of pain, including chemical, mechanical, and heat pain, as well as neuropathic, inflammatory, and cancer pain [172, 173]. The endocannabinoid system also is involved in the regulation of nociception [3].
11 Ιουλ 2022 · Endocannabinoid signalling is considered one of the most important modulatory systems in a whole organism. Research has yielded great insight on the mechanisms that link endocannabinoids and...
22 Ιαν 2019 · The endocannabinoids, cannabinoid receptors, and the enzymes/proteins responsible for their biosynthesis, degradation, and re-updating constitute the endocannabinoid system.
1 Απρ 2016 · Exogenous cannabinoids, such as tetrahydrocannabinol, produce their biological effects through their interactions with cannabinoid receptors. The best-studied endogenous cannabinoids are 2-arachidonoyl glycerol and arachidonoyl ethanolamide (anandamide).
11 Αυγ 2021 · What is the ECS? The ECS comprises a vast network of chemical signals and cellular receptors that are densely packed throughout our brains and bodies. The "cannabinoid" receptors in the brain — the CB1 receptors — outnumber many of the other receptor types on the brain.
18 Αυγ 2022 · In both animal and human studies, cannabinoid receptors, particularly CNR1, and FAAH have been found to modulate food intake. In goldfish, it has been found that food deprivation leads to increased CNR1 expression in the brain, which is lowered upon refeeding or upon administration of AEA .
