Αποτελέσματα Αναζήτησης
Expression of cannabinoid type 1 and type 2 (CB 1 and CB 2) receptors in neural tissue. The endocannabinoid system is present in neurons, astrocytes, oligodendrocytes, oligodendrocyte precursor cells (OPCs), and microglia.
11 Αυγ 2021 · All of us have tiny cannabis-like molecules floating around in our brains. The cannabis plant, which humans have been using for about 5,000 years, essentially works its effect by hijacking this ancient cellular machinery.
A,B) First identification of the chemical structure with its absolute configuration of the psychoactive compound in marijuana, Δ 9-THC (Gaoni and Mechoulam 1967).C) First demonstration by competitive inhibition of the existence of a high affinity, stereoselective, pharmacologically distinct cannabinoid receptor in brain tissue (Devane et al., 1988).
12 Δεκ 2019 · Endocannabinoid signalling is involved in regulation of cell, tissue, organ and organism homeostasis, brain development, neurotransmitter release and synaptic plasticity, and cytokine release...
29 Ιουλ 2020 · Here, we provide an overview on the structural features of cannabinoid receptors in different functional states and the diverse ligand binding modes. The major challenges and new strategies for future therapeutic applications targeting the endocannabinoid system (ECS) are also discussed.
21 Ιουλ 2020 · Recent structural studies have revealed that two cannabinoid receptors (CB1 and CB2) shared a conserved orthostatic binding pocket for their agonists. Notably, an extra allosteric binding...
The primary targets of the cannabinoids are thought to be cannabinoid receptors 1 (CB 1) and 2 (CB 2), which are class A G-protein coupled receptors (GCPRs).
