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11 Αυγ 2021 · To stimulate these receptors, our bodies produce molecules called endocannabinoids, which have a structural similarity to molecules in the cannabis plant. The first endocannabinoid that was discovered was named anandamide after the Sanskrit word ananda for bliss.
29 Ιουλ 2020 · Rapid progress in structural studies of cannabinoid receptors reveals their inactive, active-like, and active signaling states and provides valuable insights into ligand–receptor interactions, activation and signaling of cannabinoid receptors.
21 Ιουλ 2020 · Recent structural studies have revealed that two cannabinoid receptors (CB1 and CB2) shared a conserved orthostatic binding pocket for their agonists. Notably, an extra allosteric binding pocket...
17 Απρ 2008 · The endocannabinoid system consists of the endogenous cannabinoids (endocannabinoids), cannabinoid receptors and the enzymes that synthesise and degrade endocannabinoids. Many of the effects of cannabinoids and endocannabinoids are mediated by two G protein-coupled receptors (GPCRs), CB 1 and CB 2, although additional receptors may be involved.
The eCBs and their cognate cannabinoid receptors exhibit a number of unique properties that distinguish them from the widely studied classical amino-acid transmitters, neuropeptides, and catecholamines.
The primary targets of the cannabinoids are thought to be cannabinoid receptors 1 (CB 1) and 2 (CB 2), which are class A G-protein coupled receptors (GCPRs).
22 Ιαν 2019 · The endocannabinoids, cannabinoid receptors, and the enzymes/proteins responsible for their biosynthesis, degradation, and re-updating constitute the endocannabinoid system.
