Αποτελέσματα Αναζήτησης
22 Ιαν 2019 · The endocannabinoids, cannabinoid receptors, and the enzymes/proteins responsible for their biosynthesis, degradation, and re-updating constitute the endocannabinoid system.
29 Ιουλ 2020 · The CB1/CB2–G i complex structures reveal the activation and signaling mechanism of cannabinoid receptors through G proteins. Recent studies have shown that CB1 and CB2 are also able to transduce signals through the arrestin pathway, which is defined as the GPCR biased activation.
Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J. Neurosci. 15, 6552–6561.
The primary targets of the cannabinoids are thought to be cannabinoid receptors 1 (CB 1) and 2 (CB 2), which are class A G-protein coupled receptors (GCPRs). However, the structural similarity of GPCRs and the structural diversity of the phytocannabinoids, coupled with the anecdotal and preliminary medical studies into the physiological effects ...
21 Ιουλ 2020 · Recent structural studies have revealed that two cannabinoid receptors (CB1 and CB2) shared a conserved orthostatic binding pocket for their agonists. Notably, an extra allosteric binding...
24 Ιουλ 2020 · Strongly associated with GABAergic and glutamergic cells, their activation inhibits GABA and glutamate release, respectively (Baker et al., 2003). CB 1 receptor activation has been found to increase potassium and calcium ion channel activity; consequently, CB 1 modulates neurotransmitter release in a dose-dependent and pertussis toxin-sensitive ...
Here, we review structural data from high-resolution cryo-EM and crystallography studies that depict phytocannabinoid, endocannabinoid, and synthetic cannabinoid molecules bound to various proteins.
