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17 Απρ 2021 · Patients with higher CEA levels had a significantly higher mortality rate than those with normal or lower CEA levels. Researchers have also analyzed blood samples of patients diagnosed with gastric cancer who had been considered cured of the disease after undergoing surgery.
CEA is an intracellular adhesion molecule with a half-life of 1 to 3 days that is produced in fetal gut tissue and by epithelial tumor cells, where it helps with angiogenesis [11, 14]. An increased serum CEA level is found in malignancies such as colorectal, breast, gastric, lung, ovarian, and pancreatic cancer [11, 12].
23 Ιαν 2023 · Elevated CEA level of >5 µg/L at the time of new diagnosis of colorectal cancer is associated with poor prognosis. However, normalization of elevated CEA levels after surgery is not associated with a poor prognosis.
10 Ιαν 2024 · Doctors who suspect a person may have colon cancer may order a CEA test to check for elevated levels of the antigen. CEA in the blood can indicate the presence of cancer, but it cannot...
We identified 190,500 colorectal cancer patients between 2010-2019 with confirmed CEA status. Among them, 97,212 (51%) had elevated CEA levels at diagnosis, and 92,288 (49%) had non-elevated CEA levels. Most cases were adenocarcinoma (97.3%), with 53.4% male and 46.6% female.
High CEA levels could mean a tumor is large or has spread to other parts of your body. But CEA can’t be used for tumor staging or determining if your cancer has metastasized. Your healthcare provider may also test your CEA levels throughout cancer treatment.
In general a rising of CEA level may mean tumor progression, but a transient increase (surge phenomenon or flare) was found to be associated with a clinical benefit in patients receiving first line chemotherapy for metastatic colorectal cancer (1).
