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8 Αυγ 2023 · LDL cholesterol, or low-density lipoprotein cholesterol, is a fat that circulates in the blood, moving cholesterol around the body to where it is needed for cell repair and depositing it inside of artery walls.
8 Αυγ 2023 · LDLs are commonly referred to as the "bad" lipoproteins as they carry a very high concentration of cholesterol. When LDL levels are pathologically high, LDL deposits in the arterial wall and oxidize. Macrophages engulf these oxidized LDL particles, leading to their transformation that appears like foam, hence the name "foam" cells.
Physiology. LDL particles are formed when triglycerides are removed from VLDL by the lipoprotein lipase enzyme (LPL) and they become smaller and denser (i.e. fewer fat molecules with same protein transport shell), containing a higher proportion of cholesterol esters. [9][10] Transport into the cell.
6 Μαρ 2023 · Hypercholesterolemia (high LDL-cholesterol) is one of the major risk factors contributing to the formation of atherosclerotic plaques. These plaques lead to an increased possibility of various negative clinical outcomes, including, but not limited to, coronary artery disease.
30 Ιαν 2019 · LDL cholesterol is an important contributor to the risk of coronary heart disease, and its measurement is central to evaluating the effects of lipid-modifying therapies.
8 Αυγ 2023 · LDL cholesterol, or low-density lipoprotein cholesterol, is a fat that circulates in the blood, moving cholesterol around the body to where it is needed for cell repair and depositing it inside of artery walls.
17 Δεκ 2019 · The cellular cholesterol level reflects the dynamic balance between biosynthesis, uptake, export and esterification — a process in which cholesterol is converted to neutral cholesteryl esters...
