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Prolactin (also known as lactotropin and PRL) is a hormone that’s responsible for lactation, certain breast tissue development and contributes to hundreds of other bodily processes. Prolactin levels are normally low in people assigned male at birth (AMAB) and non-lactating and non-pregnant people.
Elevated levels of prolactin decrease the levels of sex hormones— estrogen in women and testosterone in men. [16] . The effects of mildly elevated levels of prolactin are much more variable, in women, substantially increasing or decreasing estrogen levels.
The key role of prolactin in maternal physiology has traditionally biased neuroendocrinological studies towards its functions in the brain of females, whereas the actions of this hormone in the male brain have drawn less attention.
Elevated PRL can be caused by medications use, renal failure, hypothyroidism, and by prolactinoma - PRL secreting tumors. Symptomatic hyperprolactinemia and prolactinomas should be treated to lower PRL levels, decrease tumor size, and restore gonadal function.
29 Νοε 2023 · Both males and females produce the hormone prolactin, but it is known for telling the body to make breast milk when someone is pregnant or breastfeeding. Production of prolactin takes place...
24 Ιουλ 2023 · In females, too much prolactin leads to amenorrhea (absence of menstruation), which results from the prolactin inhibition of GnRH release. In males, however, prolactin level imbalances have different clinical implications. Too much prolactin in males results in headaches and decreased libido.
21 Μαρ 2019 · Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland. Prolactin signalling occurs via a unique transmembrane prolactin receptor...
