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This Viewpoint gives an overview of the diagnosis and management of pulmonary toxicity arising from cancer immunotherapy, including widely used treatments, such as immune checkpoint inhibitors, and emerging therapies, such as chimeric antigen receptor T cells.
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Selected case examples of checkpoint inhibitor associated...
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Respiratory arrest is a serious medical condition caused by apnea or respiratory dysfunction severe enough that it will not sustain the body (such as agonal breathing). Prolonged apnea refers to a patient who has stopped breathing for a long period of time.
28 Δεκ 2018 · Infectious acute respiratory failure and sepsis remain the leading causes of medical-oncologic ICU admissions; however, we are seeing a surge in elderly patients presenting with disease- or treatment-associated critical illness and unique toxicities associated with newer therapies.
Treatment. Respiratory arrest and cardiac arrest are distinct, but inevitably if untreated, one leads to the other. (See also Respiratory Failure, Dyspnea, and Hypoxia.) Interruption of pulmonary gas exchange for > 5 minutes may irreversibly damage vital organs, especially the brain.
22 Φεβ 2021 · Patients with dyspnea because of underlying malignancy (eg, lymphangitic carcinomatosis, atelectasis because of large pulmonary mass, malignant pleural effusion) may benefit from cancer-directed treatments if consistent with their wishes, prognosis, and overall health status (good practice statement). 2.3.
Respiratory arrest is clinically obvious; treatment begins simultaneously with diagnosis. The first consideration is to exclude a foreign body obstructing the airway; if a foreign body is present, resistance to ventilation is marked during mouth-to-mask or bag-valve-mask ventilation.
28 Ιαν 2019 · Supportive care directed at the underlying root cause of a cancer patient’s respiratory deterioration remains the goal of critical care admission. Treatment of type I respiratory failure should include oxygen therapy, whereas ventilatory support should be utilized in patients with hypercapnia.
