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Uracil (/ ˈ j ʊər ə s ɪ l /) (symbol U or Ura) is one of the four nucleotide bases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine (T). Uracil is a demethylated form of thymine.
19 Ιαν 2021 · Uracil has a molar mass of 112.08676 g/mol and a melting point of 335 °C. It may occur as a component of a nucleoside (nucleobase + sugar deoxyribose or ribose) or of a nucleotide (nucleoside with phosphate groups). It is also one of the five primary (canonical) nucleobases in nucleic acids.
6 ημέρες πριν · Uracil (U) is one of the four nucleotide bases in RNA, with the other three being adenine (A), cytosine (C) and guanine (G). In RNA, uracil pairs with adenine. In a DNA molecule, the nucleotide thymine (T) is used in place of uracil.
16 Ιαν 2023 · Uracil is a base analogue of thymine and is found in both DNA and RNA (Figure 1). As a pyrimidine nucleotide it has an amino acid group at the 2′ position and a carboxy group at the 5′ position. U and T are equivalent in their information storage, transmission and their base pairing with adenine.
Uracil is a product of spontaneous deamination of cytosine and is potentially mutagenic. The monofunctional UNG DNA glycosylase is the main defense against uracil residues in DNA. It co-localizes with RPA and PCNA and is believed to remove uracil during replication (Fortini et al., 2003).
10 Αυγ 2020 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...
