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Therefore, if there were an organism that used uracil in its DNA, the deamination of cytosine (which undergoes base pairing with guanine) would lead to formation of uracil (which would base pair with adenine) during DNA synthesis. Uracil-DNA glycosylase excises uracil bases from double-stranded DNA.
During the synthesis of an RNA strand from a DNA template (transcription), uracil pairs only with adenine, and guanine pairs only with cytosine. Uracil is also a component of several coenzymes that act in conjunction with enzymes in several processes of carbohydrate metabolism.
19 Ιαν 2021 · Nucleic acids such as DNA and RNA molecules contain the genetic code for a particular protein based on the sequence of nucleobases. Nucleic acids hold an important role in cellular functions, heredity, and survival of an organism. Uracil is also a constituent of nucleotides UMP, UDP, and UTP.
10 Αυγ 2020 · In this paper we will review: (i) sources of the origin of uracil in DNA; (ii) some properties of the enzymes responsible for the excision of uracil and their role in the Ig diversification process, which comprises somatic hypermutation and class switch recombination; and (iii) consequences of cytosine deamination in other than the Ig loci, in ...
6 ημέρες πριν · Uracil (U) is one of the four nucleotide bases in RNA, with the other three being adenine (A), cytosine (C) and guanine (G). In RNA, uracil pairs with adenine. In a DNA molecule, the nucleotide thymine (T) is used in place of uracil.
16 Ιαν 2023 · Uracil is a base analogue of thymine and is found in both DNA and RNA (Figure 1). As a pyrimidine nucleotide it has an amino acid group at the 2′ position and a carboxy group at the 5′ position. U and T are equivalent in their information storage, transmission and their base pairing with adenine.
16 Δεκ 2002 · Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA...
