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The name biotin derives from the Greek word bios ('to live') and the suffix "-in" (a general chemical suffix used in organic chemistry). [5] Other research groups, working independently, had isolated the same compound under different names.
26 Σεπ 2024 · Biotin was first identified as a nutritive requirement of yeast. Originally called vitamin H, it was isolated in pure form in 1935; its structure was established in 1942, after it had been shown to be required by animals.
Abstract. The aim was to describe the discovery of niacin, biotin, and pantothenic acid. By the 1920s, it became apparent that 'water-soluble B' (vitamin B) is not a single substance.
Like many vitamins, biotin was "discovered" several times by different people and was given a new name by each of its discoverers. In the 1920s different researchers isolated a growth factor for yeast that some named "bios," and others called "vitamin H".
Biotin was discovered in nutritional experiments that revealed a factor in many foodstuffs that was capable of curing the scaly dermatitis, hair loss, and neurologic signs induced in rats fed dried egg whites. Avidin, a glycoprotein found in egg whites, binds biotin very specifically and tightly (Ka = 10 15 mol/L) (1, 2).
23 Οκτ 2012 · In 1940, Snell developed a yeast assay system for biotin and using this Snell and Williams isolated the protein in egg white that tightly binds biotin and causes ‘egg white injury’ (Eakin et al. 1940). This was named ‘avidin’ because of its peculiar biotin-binding capacity.
It was discovered in the 1930s by researchers experimenting with different diets for chickens and rats, and later it was discovered to be essential to human health. Bacteria, yeasts, mold, algae, and some plants make biotin. The human large intestine (colon) contains some bacteria that synthesize biotin.
