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The name biotin derives from the Greek word bios ('to live') and the suffix "-in" (a general chemical suffix used in organic chemistry). [5] Other research groups, working independently, had isolated the same compound under different names.
26 Σεπ 2024 · Biotin was first identified as a nutritive requirement of yeast. Originally called vitamin H, it was isolated in pure form in 1935; its structure was established in 1942, after it had been shown to be required by animals.
23 Οκτ 2012 · In 1936, F. Kögl and B. Tönnis succeeded in crystallizing 4 mg of bios IIb from 1000 duck egg yolks and named it biotin (Kögl and Tönnis 1936). The chemical structure ( Figure 1.4 ) was determined by V. du Vigneaud and associates in 1942, and synthesized by Folkers’ group in 1945.
Paul György (April 7, 1893 – March 1, 1976) was a Hungarian-born American biochemist, nutritionist, and pediatrician best known for his discovery of three B vitamins: riboflavin, B 6, and biotin.
Biotin was discovered in nutritional experiments that revealed a factor in many foodstuffs that was capable of curing the scaly dermatitis, hair loss, and neurologic signs induced in rats fed dried egg whites. Avidin, a glycoprotein found in egg whites, binds biotin very specifically and tightly (Ka = 10 15 mol/L) (1, 2).
They entered the field of biochemistry in the late 1930s when the race was on to discover new enzymes, cofactors, and metabolic cycles.
Biotin, an essential micronutrient for all mammals, is a mem-ber of the B complex group of vitamins. Biotin was discovered in nutritional experiments that revealed a factor in many food-stuffs that was capable of curing the scaly dermatitis, hair loss, and neurologic signs induced in rats fed dried egg whites.
