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17 Μαΐ 2024 · Iron has a key role in multiple important cellular processes, including gene regulation, metabolism, bioenergetics, and hormone synthesis. Iron deficiency is globally widespread and associated with several and diverse impacts on health, the underlying mechanisms of which are poorly understood.
Iron deficiency is globally prevalent, causing an array of developmental, haematological, immunological, neurological, and cardiometabolic impairments, and is associated with symptoms ranging from chronic fatigue to hair loss. Within cells, iron is utilised in a variety of ways by hundreds of different proteins.
2 Οκτ 2023 · Highly orchestrated regulatory systems control cellular and systemic iron fluxes ensuring sufficient iron delivery to target proteins is maintained, while limiting its potentially deleterious...
1 Οκτ 2020 · Most cells acquire iron from transferrin via receptor-mediated endocytosis (Wang and Pantopoulos, 2011). Thus, differic transferrin binds to transferrin receptor 1 (TfR1) and the complex undergoes endocytosis in clathrin-coated vesicles (Fig. 3).
Most of the iron taken up by a cell is imported into the mitochondrion for the synthesis not only of haem but also of iron-sulphur clusters (ISCs). These are cofactors made up of iron cations and sulphide anions.
12 Μαρ 2014 · The labile cell iron (LCI) composition varies with metal concentration and substances with chelating groups but also with pH and the medium redox potential. Although physiologically in the lower μM range, LCI plays a key role in cell iron economy as cross-roads of metabolic pathways.
Blood carries oxygen and nutrients to living cells and takes away their waste products. It also delivers immune cells to fight infections and contains platelets that can form a plug in a damaged blood vessel to prevent blood loss. Through the circulatory system, blood adapts to the body's needs.
