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Risks with the use of FFP include potential for initial worsening of angioedema (specifically in hereditary angioedema due to its bradykinin content), viral transmission, delayed administration time, allergic/transfusion reactions, and volume overload .
3 Φεβ 2016 · Given the challenge facing emergency physicians managing life-threatening acute AE with airway compromise, we investigated the use of FFP to examine its ability to prevent intubation and shorten the course of airway angioedema and hence ICU stays.
1 Ιαν 2016 · Angioedema (AE) is a common condition which can be complicated by laryngeal edema, having up to 40% mortality. Although sporadic case reports attest to the benefits of fresh frozen plasma (FFP)...
Objective: To report the case of a patient with ACE inhibitor–induced angioedema treated with fresh frozen plasma (FFP). Methods: The patient is a 43-year-old, white woman who first received the ACE inhibitor ramipril in March 2002.
FFP has been shown to be of benefit in hereditary angioedema, in which its main action is to replace the deficient C1 esterase inhibitor. In the treatment of ACE-I angioedema, FFP might provide further kininase II, which breaks down accumulated bradykinin, and might also provide functional enzyme in those patients with enzyme defects in ...
The key findings of our study include: (1) FFP is effective, although the time-to-resolution is considerably slower than reported for targeted therapies; (2) FFP has a TEAE rate of ~5%, and premedication may reduce TEAEs; (3) setting-specific differences in acute HAE management and FFP use exist including speed of access to FFP therapy ...
3 Φεβ 2016 · In an emergency department setting, the use of FFP should be considered in managing acute airway nonhereditary AE (refractory to steroid, antihistamine, and epinephrine). Larger prospective, better controlled studies are needed to devise appropriate treatment guidelines.
