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Risks with the use of FFP include potential for initial worsening of angioedema (specifically in hereditary angioedema due to its bradykinin content), viral transmission, delayed administration time, allergic/transfusion reactions, and volume overload .
3 Φεβ 2016 · Given the challenge facing emergency physicians managing life-threatening acute AE with airway compromise, we investigated the use of FFP to examine its ability to prevent intubation and shorten the course of airway angioedema and hence ICU stays.
5 Μαρ 2024 · For angioedema patients, FFP may be used in emergency settings to rapidly control life-threatening attacks that do not respond to other treatments, or when appropriate therapies are not readily available.
11 Αυγ 2020 · This is the first time the successful treatment of hereditary angioedema with FFP has been reported from Pakistan. In the absence of targeted therapy in most LMICs, FFP is an alternative therapeutic option for the acute management of HAE.
Why Do You Give FFP For Angioedema? Fresh-frozen plasma from a healthy donor contains the C1 inhibitor that is lacking or dysfunctional in someone with hereditary angioedema. Transfusions of FFP can help reduce excess bradykinin in the blood of someone with hereditary angioedema, preventing or treating acute attacks.
However, there is growing evidence that fresh frozen plasma (FFP) has shown beneficial results when treating refractory bradykinin-mediated angioedema caused by ACEI use. Given the risk for potential airway compromise and obstruction, FFP should be considered early to prevent the need for intubation.
a Department of Emergency and Critical Care Medicine, Sri Gokulam Hospitals and Research Institute, Salem. b Department of Emergency Medicine, Christian Medical College and Hospital, Vellore. c Department of Forensic Medicine and Toxicology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore. d Department of Internal Medicine, Chennai Medical College Hospital and Research ...
