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Our case illustrates an example of the successful use of FFP for the treatment of life-threatening ACE-IAE refractory to conventional therapy. Physicians treating patients presenting with severe ACE-IAE should keep this treatment in mind when steroids, antihistamines, and epinephrine fail to reverse symptoms.
12 Οκτ 2019 · Plasma (fresh-frozen) remains the only available effective on-demand treatment for acute HAE in many countries. FFP is effective and safe, but time-to-resolution is slower and adverse events are more frequent than published data on targeted therapies.
Transfusions of FFP can help reduce excess bradykinin in the blood of someone with hereditary angioedema, preventing or treating acute attacks. Before a possible trigger, such as a surgery or stressor, FFP can be given intravenously to help prevent dangerous swelling.
3 Φεβ 2016 · Given the challenge facing emergency physicians managing life-threatening acute AE with airway compromise, we investigated the use of FFP to examine its ability to prevent intubation and shorten the course of airway angioedema and hence ICU stays.
5 Μαρ 2024 · Benefits of fresh frozen plasma. Treatment options for bradykinin-mediated angioedema range from a C1-esterase inhibitor concentrate (C1-INH), which contain a working version of the protein of the same name, to medications that block the action of kallikrein or bradykinin.
Fresh frozen plasma (FFP) may be used to replete ACE and C1-INH and is less cost-prohibitive than other targeted therapies. FFP carries a risk of hypersensitivity reactions, infection transmission, volume-associated circulatory injuries, and worsening angioedema symptoms [6,13].
11 Αυγ 2020 · In the absence of targeted therapy in most LMICs, FFP is an alternative therapeutic option for the acute management of HAE. We need comparative studies between targeted therapies and FFP to establish its use for this rare condition, especially in resource-poor settings.
