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Risks with the use of FFP include potential for initial worsening of angioedema (specifically in hereditary angioedema due to its bradykinin content), viral transmission, delayed administration time, allergic/transfusion reactions, and volume overload .
11 Αυγ 2020 · FFP treatment offered in a timely manner to our patient resulted in the complete resolution of angioedema and was a lifesaver. Alloimmunization and volume overload, known as the adverse effects of FFP usage, were also not observed in our patient.
ACE-I related angioedema is a well-recognized side effect; in rare instances, it can be life-threatening. The estimated incidence of angioedema during ACE-I treatment is 0.1% to 0.2%.
4 Σεπ 2024 · Angiotensin-converting enzyme (ACE) inhibitors are the leading cause of drug-induced angioedema in the United States because they are so widely prescribed. Patients most commonly present with swelling of the lips, tongue, or face, although another presentation is episodic abdominal pain due to intestinal angioedema.
5 Μαρ 2024 · Benefits and risks of fresh frozen plasma. Unlike acute allergic angioedema, which occurs as a result of an allergic reaction, bradykinin-mediated angioedema may not respond to conventional medications, such as antihistamines, corticosteroids, or epinephrine (the EpiPen’s active ingredient)
12 Οκτ 2019 · Plasma (fresh-frozen) remains the only available effective on-demand treatment for acute HAE in many countries. FFP is effective and safe, but time-to-resolution is slower and adverse events are more frequent than published data on targeted therapies.
3 Φεβ 2016 · Side effects of FFP include alloimmunization, anaphylactic or allergic reaction, infection transmission (viral, Creutzfeldt-Jakob disease), and intravascular volume overload. However, the related risks must be weighed carefully against the danger of a life-threatening airway compromise .
