Αποτελέσματα Αναζήτησης
1 Φεβ 2023 · After a thorough literature review, we found two studies regarding the anticancer effects of mangosteen on liver cancer cells. When the hepatocellular carcinoma cell line HepG2 was treated with mangosteen epicarp and endocarp, they induced apoptosis through decreased cyclin D and increased p53 and caspase-3 [122].
Data from in vitro and animal studies revealed that it has antioxidant, antiinflammatory, and antiproliferative effects against cancer cells. Xanthones, the major components of mangosteen fruit, have been implicated in such effects. It is yet to be studied in humans.
Based on this information, this review presents compelling evidence for the use of mangosteen not only to prevent but also to treat cancer due to the similar molecular targets that affect tumor initiation, promotion, and progression.
3 Ιαν 2023 · Out of the limited in vivo studies that have been conducted using mangosteen extracts, there have been consistent results showing the antitumor activity of mangosteen extracts in colon cancer.
1 Ιαν 2022 · In COLO 205, CX-1, MIP-101, and SW620 colon cancer cell lines, a mangosteen pericarp extract had anti-proliferative effects at IC 50 s of 7.5, 17.7, 10, and 16.1 µg/mL [113].
23 Μαΐ 2013 · The majority of in vivo studies examining the anti-cancer activity of mangosteen xanthones have focused on colon cancer. Dietary administration of α-MG significantly inhibited the induction and development of aberrant crypt foci (ACF) in a chemically-induced rat model of colon carcinogenesis.
Of the 68 mangosteen xanthones identified so far, the most widely-studied are α-mangostin and γ-mangostin. Emerging studies have found that mangosteen constituents and phytochemicals exert encouraging antineoplastic effects against a myriad of human malignancies.
