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  1. Please call your healthcare provider if you have questions about XYREM, or you can contact the REMS toll free at 1-866-997-3688. You can reach a pharmacist at this number 24 hours a day, 7 days a week with any questions. We hope you find this information and the REMS services helpful. Sincerely, Jazz Pharmaceuticals.

  2. XYREM: an oxybate treatment for 2 common narcolepsy symptoms. XYREM is approved to treat cataplexy and/or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. It is taken at night to help relieve these symptoms that occur during the day.

  3. Never run out of your medication. Refilling your XYREM is easy and convenient with our online refill scheduling and reminder. Sign up to receive email and text reminders today. Call the pharmacy at 1-866-997-3688 to sign up! Nursing Support

  4. Need help? Have questions? Get answers. For further information, visit or call. XYWAVXYREMREMS.com. 1-866-997-3688. A JazzCares ® Nurse Case Manager is available. Monday – Friday, 7 AM – 8 PM, Central Time. A pharmacist is available 24 hours a day, 7 days a week. Important Safety Information.

  5. For more information, call the XYWAV and XYREM REMS at 1-866-997-3688 (toll free). Note: Use this form to enroll patients in the XYWAV and XYREM REMS for either product. Please Print (*denotes required field)

  6. Form available online at www.XYWAVXYREMREMS.com. Either submit online, OR print, sign, and: Fax to XYWAV and XYREM REMS: 1-866-470-1744 (toll free) OR mail to XYWAV and XYREM REMS, PO Box 66589, St. Louis, MO 63166-6589.

  7. Success Program by calling the following toll-free phone number: 1-866- 5XYREM5 (1-866-599-7365). Treatment should be initiated by and remain under the guidance of a physician.

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