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  1. Never run out of your medication. Refilling your XYREM is easy and convenient with our online refill scheduling and reminder. Sign up to receive email and text reminders today. Call the pharmacy at 1-866-997-3688 to sign up!

  2. Please call your healthcare provider if you have questions about XYREM, or you can contact the REMS toll free at 1-866-997-3688. You can reach a pharmacist at this number 24 hours a day, 7 days a week with any questions. We hope you find this information and the REMS services helpful. Sincerely, Jazz Pharmaceuticals.

  3. XYREM: an oxybate treatment for 2 common narcolepsy symptoms. XYREM is approved to treat cataplexy and/or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. It is taken at night to help relieve these symptoms that occur during the day.

  4. Patient Support Programs JazzCares: 1-833-533-JAZZ (5299) For Defitelio ® , Rylaze ™ , Vyxeos ® , Xyrem ® , Xywav ® , or Zepzelca ® support, contact JazzCares via phone or visit JazzCares.com .

  5. Need help? Have questions? Get answers. For further information, visit or call. XYWAVXYREMREMS.com. 1-866-997-3688. A JazzCares ® Nurse Case Manager is available. Monday – Friday, 7 AM – 8 PM, Central Time. A pharmacist is available 24 hours a day, 7 days a week. Important Safety Information.

  6. The online REMS Patient Enrollment Form can be found here. Submit the completed and signed front page of the XYWAV Prescription Form to the Certified Pharmacy by either: Online. XYWAVXYREMREMS.com. Fax. 1-866-470-1744 (toll-free) Mail. XYWAV and XYREM REMS PO Box 66589 St. Louis, MO 63166-6589. Keep the following additional information in mind.

  7. Xyrem Phone: 215-991-4300 Fax back to: 866-240-3712 Health Partners Plans manages the pharmacy drug benefit for your patient. Certain requests for coverage require review with the prescribing physician. Please answer the following questions and fax this form to the number listed above.

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