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When stratified by dietary zinc intake (< 11 vs. ≥11 mg/day), supplemental zinc of ≥ 101 mg/day or ≥ 15 years were associated with increased risk of lethal and aggressive prostate cancer in both groups, while significant trend tests were seen in high dietary zinc group but not the other (eTable 1).
- Zinc as a complementary treatment for cancer patients: a ... - PubMed
The patients treated with zinc were mainly diagnosed with...
- Zinc as a complementary treatment for cancer patients: a ... - PubMed
26 Ιαν 2021 · With respect to cancer, several in vitro and in vivo studies point to beneficial effects via the immune system by activating macrophages. Zinc modulates oxidative stress and might help to prevent cancer [7]. In case reports, an improvement of the effects of chemotherapy has been described [8].
The transporter-mediated imbalance of intracellular zinc can contribute to the development and progression of cancer, including prostate cancer (A), breast cancer (B), pancreatic cancer (C), esophageal cancer, and metastatic cancers (D).
The decrease in zinc is due to the down regulation of the ZIP-family zinc uptake transporter. These cells are as "ZIP-deficient/decreased zinc" malignancies. This provides a target for a chemotherapy that can restore the high zinc levels that will manifest cytotoxic effects in the malignant cells.
The patients treated with zinc were mainly diagnosed with head and neck cancer and underwent chemo-, radio- or concurrent radio-chemotherapy. Interventions included the intake of different amounts of zinc supplements and oral zinc rinses.
1 Ιουλ 2022 · Preparation and clinical evaluation of a novel lozenge containing polaprezinc, a zinc-L-carnosine, for prevention of oral mucositis in patients with hematological cancer who received high-dose chemotherapy
The patients treated with zinc were mainly diagnosed with head and neck cancer and underwent chemo-, radio- or concurrent radio-chemotherapy. Interventions included the intake of diferent amounts of zinc supplements and oral zinc rinses.