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10 Ιουλ 2018 · Researchers from the University of Oxford (UK) have developed computer simulations that are able to outperform animal models in drug trials to predict the clinical risk of drug-induced arrhythmias. The group were able to test a new cardiac drug in a virtual human for adverse side effects with an accuracy of 89–96%.
26 Φεβ 2020 · We review the accelerating development of computer-based approaches to replace animal tests. A new article by our science team, which reviews the development of computer-based techniques to replace animal tests over the past two decades, has been published in the scientific journal Computational Toxicology.
1 Ιουν 2023 · Regulators will now allow cell-based testing and even computer modeling, in addition to or instead of animal testing. Organoids, organs-on-a-chip, and in silico testing are being...
Various alternatives to the use of animals have been suggested, such as in vitro models, cell cultures, computer models, and new imaging/analyzing techniques (Balls, 2002). The in vitro models provide the opportunity to study the cellular response in a closed system, where the experimental conditions are maintained.
1 Ιαν 2022 · Schematic overview of various alternatives to animal testing. Computer-based modeling and screening, conventional chemical laboratory experiments, in vitro cell-free extract-based methods, cell-based 2D and 3D assay systems, and tissues excised from spent animals or human donors are some of the approaches to alternative toxicological screening.
A number of major breakthroughs in basic science and medical research have been possible because of observations and testing on animal models. Most vaccines, which save millions of human and animal lives every year, have been successfully developed using animal models. ... biochemistry, genomics, cell culture, computer modeling, animal model ...
The study by the Computational Cardiovascular Science team demonstrated that human computer models of heart cells are more accurate than animal experiments at predicting the drug-induced side effects for the heart in humans.
