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3 Μαΐ 2011 · Plasma was treated with β-glucuronidase/sulfatase to hydrolyze glucuronide and sulfate conjugates of daidzein and genistein. Plasma concentrations of daidzein and genistein were determined by high performance liquid chromatography.
29 Ιουν 2022 · Genistein potentiated its antiproliferative and antioxidant effects on HT29 human colon cancer cells after encapsulation with PEGylated silica nanoparticles by modulating endogenous antioxidant enzymes and H 2 O 2 production, simultaneously activating apoptosis and autophagy, unlike free genistein, which only activates apoptosis in a lower ...
The genistein nanomaterials start their antiproliferative and antioxidant activity on human colon cancer cell lines (HT29) and activate apoptosis and autophagy, unlike free genistein which only activates apoptosis in a low quantity . In colon cancerous cells and tissues, CpG islands methylation in the promoter region decreased Wnt inhibitory ...
Genistein is an iso avone rst isolated from the brooming plant Dyer’s Genista tinctoria L. and is widely distributed in the Fabaceae fl fi family. As an iso avone, mammalian genistein exerts estrogen-like functions.
Genistein controls the metastasis process, the main cause of liver cancer. This process may be controlled by levels of epithelial factors α-catenin, E-cadherin, and mesenchymal factors N-cadherin and vimentin. Genistein decreases levels of mesenchymal factors and increases levels of epithelial factors.
1 Απρ 2016 · A plethora of evidence supports the in vitro and in vivo anticancer effects of genistein, a soybean isoflavone. Major tumors affected by genistein here reviewed are breast, prostate, colon, liver, ovarian, bladder, gastric, brain cancers, neuroblastoma and chronic lymphocytic leukemia.
15 Αυγ 2023 · Genistein is structurally 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one or 4′,5,7-trihydroxyisoflavone, and it serves as a precursor in the biosynthesis of antimicrobial phytoalexins and phytoanticipins in legumes.
