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How is chordoma treated? The go-to treatment option for chordoma is surgery. Total surgical removal of the tumor (en bloc resection) has the best chance of prolonging survival.
14 Νοε 2020 · Chordoma treatment depends on the size and location of the cancer, as well as whether it has invaded nerves or other tissue. Options may include surgery, radiation therapy, radiosurgery and targeted therapies.
In this review article, the pathophysiology, diagnosis and modern treatment paradigms of chordoma will be discussed with an emphasis on the ongoing research and advances in the field that may lead to improved outcomes for patients with this challenging disease.
Monotherapy of TKIs is recommended as the first-line management, and combination therapy (two TKIs or TKI plus mTOR inhibitor) may be the choice for drug-resistant chordoma. Brachyury vaccine is a promising therapeutic strategy and requires more clinical trials to evaluate its safety and efficacy.
How should chordoma be treated? The Chordoma Global Consensus Group is a multidisciplinary, international group of over 60 doctors who specialize in caring for chordoma patients. This group of experts has developed consensus treatment guidelines based on all available medical and scientific evidence on chordoma treatment and patient outcomes.
Chordomas are thought to arise from transformed remnants of notochord and have a predilection for the axial skeleton, with the most common sites being the sacrum, skull base, and spine. The gold standard treatment for chordomas of the mobile spine and sacrum is en-bloc excision with wide margins and postoperative external-beam radiation therapy.
7 Αυγ 2023 · Overall 5-year survival is approximately 50%, and treatment is en bloc surgical resection followed by high-dose conformal radiation therapy such as proton beam radiation.[1][2] A chordoma is a low-grade, slow-growing, but locally invasive and locally aggressive tumor.
