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Chromium toxicity refers to any poisonous toxic effect in an organism or cell that results from exposure to specific forms of chromium—especially hexavalent chromium. [1] Hexavalent chromium and its compounds are toxic when inhaled or ingested.
11 Ιαν 2024 · The prognosis for acute chromium toxicity is generally excellent, with deaths noted primarily from massive ingestions. Cancerous lesions due to chronic toxicity, however, may go undetected until the advanced disease burden causes systemic symptoms.
30 Αυγ 2022 · Chronic exposure and bioaccumulation of chromium, as a heavy metal, can cause toxicity and numerous pathophysiological defects, including allergic reactions, anemia, burns, and sores especially in the stomach and small intestine, damage to sperm along with the male reproductive system, and affect various biological systems.
12 Μαρ 2020 · The mechanism of action of Cr and its compounds in humans is not yet fully understood. Currently, three possible mechanisms have been proposed for carcinogenesis: Cr (VI)-induced multistage carcinogenesis, genomic instability, and epigenetic modification.
The lower toxicity of chromium(III) acetate compared with chromium(III) nitrate may be related to solubility; chromium(III) acetate is less soluble in water than is chromium(III) nitrate. Signs of toxicity included hypoactivity, lacrimation, mydriasis, diarrhea, and change in body weight.
While it is well documented that exposure to chromium in the environment is pervasive, and that hexavalent chromium is a potent carcinogen, there are multiple mechanisms by which chromium exposure induces cellular damage and adverse health effects.
