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Clopidogrel is an antiplatelet agent that prevents blood clots in various cardiovascular diseases. It is a prodrug that is activated by CYP enzymes and inhibits P2Y12 receptors on platelets.
10 Ιουλ 2023 · Mechanism of Action. Clopidogrel is an irreversible inhibitor of the platelet P2Y12 adenosine diphosphate receptor. Inhibition of this receptor prevents the downstream activation of the glycoprotein IIb/IIIa receptor complex, which leads to reduced platelet aggregation.
Clopidogrel (top left) being activated: The first step is an oxidation mediated (mainly) by the enzyme CYP2C19, unlike the activation of the related drug prasugrel. The two structures at the bottom are tautomers of each other; and the final step is a hydrolysis.
17 Φεβ 2020 · Clopidogrel is an antiplatelet agent that requires biotransformation to an active metabolite. It inhibits platelet aggregation dose-dependently and has a half-life of ~6 hours. Learn about its indications, contraindications, interactions, and warnings.
21 Μαρ 2024 · Clopidogrel is a medication that lowers your risk of having a stroke, blood clot, or serious heart problem after a heart attack or other conditions. It works by preventing your blood from clotting and can cause bleeding problems. Learn more about its dosage, interactions, and precautions.
Clopidogrel is used alone or together with aspirin to lessen the chance of a heart attack or stroke. It is given to patients with acute coronary syndrome (ACS), to patients who have already had a heart attack, severe chest pain, or a stroke, or to patients with other circulation problems (eg, peripheral arterial disease) that could cause a ...
Clopidogrel is an antiplatelet medication that prevents blood clots and reduces the risk of heart attack or stroke. Learn how to use it, what side effects to watch out for, and what to do if you stop taking it.
