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This chapter describes the conditioning theory of tolerance, summarizes the data which supports the theory, discusses the relevance of the theory to drug dependence, and presents the implications ofthe theory for the treatment of drug abuse.
- Classical Conditioning, Drug Tolerance, and Drug Dependence - Springer
This chapter describes the conditioning theory of tolerance,...
- Drug Conditioning - SpringerLink
This effect can result in conditioned tolerance (Siegel et...
- Classical Conditioning, Drug Tolerance, and Drug Dependence - Springer
This chapter describes the conditioning theory of tolerance, summarizes the data which supports the theory, discusses the relevance of the theory to drug dependence, and presents the implications of the theory for the treatment of drug
This chapter describes the way drug use can be thought of in terms of classical conditioning, the ways in which conditioning processes are thought to affect drug taking behaviour, and the implications of the analysis for the development of treatments for addiction.
1 Μαΐ 2016 · In neuropsychiatric drug development, the rate of successful translation of preclinical to clinical efficacy has been disappointingly low. Tolerance, defined as a loss of efficacy with repeated drug exposure, is rarely addressed as a potential source of clinical failures.
This effect can result in conditioned tolerance (Siegel et al. 2000). With conditioned tolerance, a higher dose of a drug can be tolerated when external stimuli associated with prior administration of the drug are present. If such stimuli are absent, administration of the drug may lead to an overdose.
A model that extrapolates the biological consequences of drug administration to account for acute and chronic tolerance and shows how neural responses following drug administration are often obscured and provides a reinterpretation of drug conditioning paradigms is presented.
Main topics discussed in this article include the following: (1) heroin overdose and heroin tolerance; (2) learning and drug tolerance; and (3) Pavlovian conditioning and tolerance to the lethal effects of drugs.
